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MTBP Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA519979
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Descrizione
In Western blot applications, this antibody detects a band at ∽104kDa. A suggested positive control is K562 cell lysate. PA5-19979 can be used with blocking peptide PEP-0103.
MTBP inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. The protein may play a role in MDM2-dependent TP53/p53 homeostasis in unstressed cells. The protein inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of TP53/p53 and its subsequent degradation.
Specifica
| MTBP | |
| Polyclonal | |
| Unconjugated | |
| Mtbp | |
| AI429604; hdm2; HDMX; hMTBP; MDM2 (mouse double minute 2)-binding protein, 104kD; MDM2 binding protein; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa; Mdm2, transformed 3T3 cell double minute p53 binding protein; mdm2-binding protein; MDM2BP; MGC5370; MGC71221; mMTBP; Mtbp; RGD1565672 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 27085 | |
| Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Immunocytochemistry, Western Blot | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| Q96DY7 | |
| Mtbp | |
| A synthetic peptide corresponding to amino acids 122 to 139 of human MTBP | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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