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Nhe-1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marca:  Invitrogen PA520444

Codice prodotto. 12848622

  • 508.00€ / 100µg

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Descrizione

Descrizione

A suggested positive control is rat kidney tissue lysate. PA5-20444 can be used with blocking peptide PEP-0561.

The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.
TRUSTED_SUSTAINABILITY
Specifica

Specifica

Nhe-1
Polyclonal
Unconjugated
SLC9A1
Apnh; APNH1; AW554487; LIKNS; Mir5122; mir-5122; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1; Na+/H+ antiporter; Na+/H+, amiloride sensitive; Na-Li countertransporter; Nhe1; NHE-1; PPP1R143; protein phosphatase 1, regulatory subunit 143; SLC9A1; slow-wave epilepsy; sodium/hydrogen exchanger 1; Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 member 1; solute carrier family 9 member A1; solute carrier family 9, member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; swe
Rabbit
Antigen affinity chromatography
RUO
20544, 24782, 6548
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Liquid
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P19634, P26431, Q61165
SLC9A1
A 20 amino acid peptide near the carboxy terminus of the human Nhe-1.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
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