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DiscoverX PathHunter™ U2OS PTGER1 β-Arrestin Cell Line

Product Code. 17394039
Encompass
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Quantità:
2 Vials
This item is not returnable. View return policy

Product Code. 17394039

Brand: DiscoverX 930937C3

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This item is not returnable. View return policy

Description

The PathHunter™ U2OS PTGER1 β-Arrestin Cell Line measures PTGER1 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ PTGER1 β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER1 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged PTGER1 and EA-tagged β-Arrestin 2. Activation of PTGER1 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry β-Arrestin Recruitment
Linea cellulare U2OS
Da utilizzare con (applicazione) Cell Lines
Primary Agonist Prostaglandin E2
Quantità 2 Vials
Target Entry PTGER1
Numero di accesso NM_000955.2
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