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PCNA Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marca:  Invitrogen PA512449

Dettagli aggiuntivi : Peso : 0.01000kg

Codice prodotto. 10008639

  • 471.00€ / 100µg
Spedizione stimata: 26-06-2024
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Descrizione

Descrizione

This antibody is predicted to react with bovine, chicken, hamster, mouse, non-human primate and rat based on sequence homology.

PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e. relevant to prognosis). PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.
Specifica

Specifica

PCNA
Polyclonal
Unconjugated
Pcna
ATLD2; cb16; Cyclin; DNA polymerase delta auxiliary protein; etID36690.10; fa28e03; fb36g03; HGCN8729; hypothetical protein LOC515499; MGC8367; Pcna; pcna protein; Pcna/cyclin; PCNAR; POL30; Proliferating cell nuclear antigen; wu:fa28e03; wu:fb36g03; YBR0811; YBR088C
Rabbit
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
5111
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
2 mg/mL
PBS with 0.09% sodium azide
P12004
Pcna
KLH conjugated synthetic peptide between 89-117 amino acids from the central region of human PCNA
400 μL
Primary
Human
Antibody
IgG
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