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RHBDD1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA566057
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Descrizione
Immunogen sequence: FLNPQKPLYSS CLSVEKCYQQ KDWQRLLLSP LHHADDWHLY FNMASMLWKG INLERRLGS Highest antigen sequence identity to the following orthologs - mouse 88%, rat 83%.
The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.
Specifica
| RHBDD1 | |
| Polyclonal | |
| Unconjugated | |
| RHBDD1 | |
| HSD50; rhomboid domain-containing protein 1 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 84236 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Immunofluorescence | |
| 0.2 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q8TEB9 | |
| RHBDD1 | |
| Recombit Human RHBDD1 | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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Titolo del prodotto
For Research Use Only
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