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Invitrogen™ RSPO2 Polyclonal Antibody

Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA525188
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Descrizione
This antibody is predicted to react with mouse based on sequence homology.
The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally-related, secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. This activity effectively activates and increases the subsequent nuclear signaling of beta-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/beta-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations.
Specifica
| RSPO2 | |
| Polyclonal | |
| Unconjugated | |
| RSPO2 | |
| 2610028F08Rik; AA673245; CRISTIN2; cristin-2; cysteine-rich and single thrombospondin domain-containing protein 2; D430027K22; ftls; hRspo2; mCristin-2; RGD1562331; Roof plate-specific spondin-2; Rspo2; R-spondin 2; R-spondin 2 homolog; R-spondin 2 homolog (Xenopus laevis); R-spondin-2; UNQ9384/PRO34209 | |
| Rabbit | |
| Antigen affinity chromatography, Protein A | |
| RUO | |
| 340419 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot | |
| 0.48 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.4 | |
| Q6UXX9 | |
| RSPO2 | |
| KLH conjugated synthetic peptide between 190-218 amino acids from the C-terminal region of human RSPO2. | |
| 400 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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