Invitrogen™ SAA Monoclonal Antibody (Reu86.1)

Descrizione

MA1-40180 detects SAA from human and mouse samples. MA1-40180 is raised against human SAA and Helix Pomatia Haemocyanine. It reacts specifically with SAA-1, the major isoform of SAA in plasma. MA1-40180 has been successfully used in immunohistochemistry (frozen and paraffin), western blot, and immunoassay applications. It is recommended that users test the reagent and determine their own optimal dillutions. The MA1-40180 immunogen is human SAA.

The serum amyloid A family comprises a number of differentially expressed apolipoproteins, acute-phase SAA1 and SAA2, the former being the major component in plasma and constitutive SAAs. Although the liver is the primary site of synthesis of both SAA types extrahepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed its importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations; SAA rises earlier and more sharply than CRP. Recently, a broader view of SAA expression and function has been emerging.