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Thermo Scientific™ SMART Digest™ Dual Enzyme Columns for HDX-MS Analysis

Codice prodotto. 18078081 Sfoglia Tutto Thermo Scientific Prodotti
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Dimensione particelle:
˜20 μm
Dimensione della confezione:
Pezzo
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Codice prodotto. Dimensione particelle Dimensione della confezione
18078081 ˜20 μm Pezzo
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Codice prodotto. 18078081 Fornitore Thermo Scientific™ N. del fornitore 60160110
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Spedizione stimata: 24-09-2026
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Descrizione

Thermo Scientific™ SMART Digest™ Dual Enzyme Columns for HDX-MS analysis provide fast, reliable digestion of proteins for HDX-MS analysis, helping to provide the sequence characterization of biotherapeutics.

Thermo Scientific SMART Digest Dual Enzyme columns containing pepsin and protease XIII provide fast, reliable digestion of proteins for for HDX-MS analysis helping to provide the sequence characterization of biotherapeutics.

SMART Digest Dual Enzyme columns for HDX-MS analysis help to provide the characterization of biotherapeutics.

The combination of enzymes are complementary, creating many short, overlapping N-terminal peptides for a high degree of sequence coverage.

Pepsin cleaves proteins preferentially at carboxylic groups of aromatic amino acids such as phenylalanine, tryptophan and tyrosine. It will not cleave at bonds containing valine, alanine or glycine. The optimum pH range for pepsin activity is 1.0–3.0.

Proteinase XIII cleaves proteins preferentially at carboxylic groups of basic amino acids (arginine, lysine, histidine). Like pepsin, Proteinase XIII is active at low pH.

TRUSTED_SUSTAINABILITY

Specifica

Tipo SMART Digest Pepsin/Protease XIII Dual Enzyme column
Descrizione SMART Digest Pepsin/Protease XIII Dual Enzyme Column
Enzyme Pepsin & Protease XIII
Cleavage Pepsin: Cleaves proteins preferentially at carboxylic groups of aromatic amino acids such as phenylalanine, tryptophan and tyrosine. The optimum pH range for pepsin activity is 1.0–3.0.

Protease XIII: Cleaves proteins preferentially at carboxylic groups of basic amino acids (arginine, lysine, histidine). Like pepsin, Proteinase XIII is active at low pH.
Da utilizzare con (applicazione) HDX-MS analysis
Formato colonna Immobilized enzyme
Diametro 2.1 mm
Portata 10 to 500 μL/min
Pressione max 2500 psi (170 bar)
Lunghezza 30 mm
Compatibilità fase mobile Phosphate buffer pH 4
Dimensione particelle ˜20 μm
pH 2 to 6
Dimensione del poro ° 1000 angstroms
Intervallo temperatura d'esercizio 4 °C to 50 °C
Temperatura di stoccaggio RT for up to 2 weeks; 4 °C for extended period (refrigerate in MES pH 6)
Fase stazionaria Immobilized enzyme
Materiale di impaccamento Hydrophilic/coated DVB
Tipo di colonna Immobilized enzyme in PEEK cartridge
Tecnica BioLC
Stabilità 1 year
Peso 8 g
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