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Invitrogen™ TLR11 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA520055
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Descrizione
A suggested positive control is RAW264.7 cell lysate. PA5-20055 can be used with blocking peptide PEP-0174.
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLR11 does not respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. TLR11-deficient mice are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating that TLR11 may play a protective role in preventing infection of internal organs of the urogenital system.
Specifica
| TLR11 | |
| Polyclonal | |
| Unconjugated | |
| Tlr11 | |
| Gm1365; Gm287; RGD1564460; RP23-392K10.4; Tlr11; Tlr12; Toll-like receptor 11; Toll-like receptor 12 | |
| Rabbit | |
| Ion-exchange chromatography | |
| RUO | |
| 239081 | |
| Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| Q6R5P0 | |
| Tlr11 | |
| A peptide corresponding to 15 amino acids near the carboxy terminus of mouse TLR11. | |
| 100 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG |
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