WBP1L Polyclonal Antibody, Invitrogen™

Descrizione

Immunogen sequence: PLSEPSRSST RPPSIADPDP SDLPVDRAAT KAPGMEPSGS VAGLGELDPG AFLDKDAECR EELLKDDSSE HGAPDSKEKT PGRHRRFTGD Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 76%.

WBP1L (OPAL1, outcome predictor in acute leukemia 1) is an almost uncharacterized transmembrane adaptor protein expressed mainly by megakaryocytes and platelets. Its expression is enhanced on TEL/AML leukemic cells. The function of OPAL1 is unknown, although the presence of a cytochrome c-like heme-binding site and a transmembrane domain suggested OPAL1 may be involved in the mitochondrial electron transport chain. Its originally reported prognostic impact appears to be treatment dependent.