missing translation for 'onlineSavingsMsg'
Learn More
Learn More
CD279 (PD-1) Mouse anti-Human, PerCP-Cy5.5, Clone: EH12.1 (also known as EH12), BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 561273
Dettagli aggiuntivi : Peso : 0.01000kg
Descrizione
The EH12.1 monoclonal antibody specifically binds to CD279. CD279 is an immunoregulatory receptor that is expressed on activated T cells, B cells and myeloid cells and contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. PD-L1 and PD-L2 are ligands of CD279 and are members of the B7 gene family. Interaction of CD279:PD-Ligands results in inhibition of T cell proliferation and cytokine secretion. Reports suggest that the B7/CTLA-4 pathway functions primarily to attenuate, limit, and/or terminate naοve T-cell activation in secondary lymphoid organs. The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery.
Specifica
| CD279 (PD-1) | |
| Monoclonal | |
| PerCP-Cyanine5.5 | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Human PD-1 Recombinant Protein | |
| 100 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| EH12.1 (also known as EH12) | |
| hPD-1; PD1; PDCD1; Programmed cell death 1; SLEB2 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Human | |
| IgG1 κ |