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B23/NPM1 Mouse anti-Human, Mouse, Rat, Clone: 4F12A3, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 60096-1-IG-20UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16897065

  • 121.38€ / 20µL

Spedizione stimata: 28-09-2022
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Descrizione

Descrizione

NPM1 (Nucleophosmin 1, B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. NPM1 continuously shuttles between the nucleus, cytoplasm, nucleolus and chaperoning core histones from the nucleus to the cytoplasm. NPM1 has been shown to bind nucleic acid, prevent protein aggregation via its chaperon activities, protect enzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM1 is associated with the centrosome, and is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division). Due to the NPM1 gene interaction with several tumor-associated chromosome translocations, NPM1 is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, NPM1 is believed to act as the interface for oligomerization and oncogenic conversion of these tumor promoting fusion proteins. Further, NPM1 is also known to sequester the tumor suppressor RF in the nucleolus, protecting it from degradation until it is necessary. Dysfunction of the NPM1 protein is associated with diseases such as acute myeloid leukemia and lymphomatoid papulosis.
Specifica

Specifica

B23/NPM1
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P06748, P13084, Q61937
Npm1
B23/NPM1 Fusion Protein Ag7415
20 μL
Primary
Human, Mouse, Rat
Antibody
IgG1
Immunohistochemistry (Paraffin), Western Blot, Immunofluorescence, Immunocytochemistry
4F12A3
Unconjugated
NPM1
B23, NPM, NPM1, Nucleophosmin, Numatrin
Mouse
Protein G
RUO
18148, 25498, 4869
-20°C
Liquid
Videos
SDS
Documenti
Certificati
Offerte speciali

Offerte speciali