Beta-2-microglobulin Mouse anti-Human, Clone: 1C3B7, Proteintech
Mouse Monoclonal Antibody
Marca: Proteintech 66207-1-IG-150UL
Dettagli aggiuntivi : Peso : 0.00010kg
DescrizioneBeta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predomitly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Western Blot, Immunohistochemistry (Paraffin)|
|B2M, Beta-2-microglobulin, HDCMA22P|