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CD47 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 20305-1-AP-20UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16899824

  • 121.38€ / 20µL

Spedizione stimata: 29-09-2022
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Descrizione

Descrizione

CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Functionally, CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. CD47 is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. CD47 has broad tissue distribution, is reduced in expression on Rh erythrocytes. CD47 acts as a ligand for CD172a (signal regulatory protein alpha, SIRP alpha), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion, T cell activation, and is involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.
Specifica

Specifica

CD47
Polyclonal
Unconjugated
CD47
CD47, CD47 molecule, IAP, Leukocyte surface antigen CD47, MER6, OA3, Protein MER6
Rabbit
Antigen Affinity Chromatography
RUO
961
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.25 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q08722
CD47
CD47 Fusion Protein Ag14132
20 μL
Primary
Human
Antibody
IgG
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Documenti
Certificati
Offerte speciali

Offerte speciali