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CDC34 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 10964-2-AP-150UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16897693

  • 325.38€ / 150µL

Spedizione stimata: 11-10-2022
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Descrizione

Descrizione

This antibody can also recognize CDC34B (UBC3B) which is highly homologous to UBC3 (CDC34) with only 47 amino acid differences.

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ′Lys-48′-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF (FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions ′Lys-21′ and/or ′Lys-22′ with a monoubiquitin. Cooperates with the SCF (SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes.
Specifica

Specifica

CDC34
Polyclonal
Unconjugated
CDC34
CDC34, E2 CDC34, UBC3, UBCH3, UBE2R1, Ubiquitin protein ligase R1
Rabbit
Antigen Affinity Chromatography
RUO
216150, 299602, 997
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin)
0.24 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P49427, Q8CFI2
CDC34
CDC34 Fusion Protein Ag1438
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
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Offerte speciali

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