COL15A1 Polyclonal Antibody, Invitrogen™

Descrizione

Immunogen sequence: MPGEVEASGV APGELDLSMS AQSLGEEATV GPSSEDSLTT AAAATEVSLS TFEDEEASGV PTDGLAPLTA TMAPERAVTS GPGDEEDLAA A Highest antigen sequence identity to the following orthologs: Mouse - 35%, Rat - 33%.

This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.