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Cyclin D1 Mouse anti-Human, Mouse, Clone: 2G3G5, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 60186-1-IG-150UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16897165

  • 325.38€ / 150µL

Spedizione stimata: 10-10-2022
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Descrizione

Descrizione

Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL). In addition, cyclin D1 positively regulates protein phosphorylation, mammary gland epithelial cell proliferation, and fat cell differentiation. In humans, the CCND1 gene encoding cyclin D1 is present on chromosome 11. Cyclin D1 is a cytoplasmic and nuclear protein that is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation. D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation, and titrate CDK inhibitors such as p21Cip1 and p27Kip1. Without growth factor-mediated stimulation, Cyclin D1 is unstable, and undergoes ubiquitin-mediated degradation, which is triggered by its phosphorylation. Cyclin D1 destabilization participates in G1/S phase arrest. The Cyclin D1 protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The Cyclin D1 protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities.
Specifica

Specifica

Cyclin D1
Monoclonal
1.5 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P24385, P25322
CCND1
Cyclin D1 Fusion Protein Ag0689
150 μL
Primary
Mouse, Human
Antibody
IgG2b
Western Blot
2G3G5
Unconjugated
CCND1
B cell lymphoma 1 protein, CCND1, cyclin D1, D11S287E, G1/S specific cyclin D1, PRAD1, PRAD1 oncogene, U21B31
Mouse
Protein A
RUO
12443, 595
-20°C
Liquid
Videos
SDS
Documenti
Certificati
Offerte speciali

Offerte speciali