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EGFR Mouse anti-Human, Clone: 2A2H10, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 66455-1-IG-20UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16898345

  • 121.38€ / 20µL

Spedizione stimata: 28-09-2022
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Descrizione

Descrizione

EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC pathways that help in growth and proliferation of cells. Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPK pathway. Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. Moreover, EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
Specifica

Specifica

EGFR
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P00533
EGFR
EGFR Fusion Protein Ag24947
20 μL
Primary
Human
Antibody
IgG1
Western Blot, Immunohistochemistry (Paraffin)
2A2H10
Unconjugated
EGFR
EGFR, ERBB, ERBB1, HER1, mENA, PIG61, Proto oncogene c ErbB 1
Mouse
Protein G
RUO
1956
-20°C
Liquid
Videos
SDS
Documenti
Certificati
Offerte speciali

Offerte speciali