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ACROBiosystems FITC-Labeled Human CD27 Ligand / CD70 Protein, His,Flag Tag active trimer
MALS verified
Marca: ACROBiosystems CDD-HF2D4-200ug
Dettagli aggiuntivi : Peso : 0.00010kg
Descrizione
Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.
This protein carries a polyhistidine tag at the N-terminus, followed by a flag tag. The protein has a calculated MW of 49.3 kDa. The protein migrates as 50-55 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.Specifica
49.3 kDa | |
FITC-Labeled Human CD27 Ligand, His,Flag Tag (CDD-HF2D4) is expressed from human 293 cells (HEK293). It contains AA Ser 52 - Pro 193 (Accession # P32970-1). It is the biotinylated form of Human CD27 Ligand, His,Flag Tag (active trimer) (MALS verified) (Cat. No.CDL-H52Da). | |
-20°C, avoid light | |
CD27 Ligand | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Fluorescent labeled protein |
200 μg | |
Ser 52 - Pro 193 | |
CD70,CD27LG,TNFSF7,TNFSF7G,CD27L | |
FITC | |
His Tag and Flag Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE |