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ACROBiosystems FITC-Labeled Human ROR1 Protein, His Tag
Marca: ACROBiosystems RO1-HF258-200ug
Dettagli aggiuntivi : Peso : 0.00010kg
Descrizione
Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 43.9 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifica
| 43.9 kDa | |
| FITC-Labeled Human ROR1, Fc Tag (RO1-HF258) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Glu 403 (Accession # Q01973-1). It is the FITC labeled form of Human ROR1, Fc Tag (RO1-H522y). | |
| -20°C, avoid light | |
| ROR1 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Fluorescent labeled protein |
| 200 μg | |
| Gln 30 - Glu 403 | |
| ROR1,NTRKR1 | |
| FITC | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |