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ACROBiosystems FITC-Labeled Human Syndecan-1 Protein, His Tag
Marca: ACROBiosystems SD1-HF228-200ug
Dettagli aggiuntivi : Peso : 0.00010kg
Descrizione
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.8 kDa. The protein migrates as 42-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifica
| NP_001006947.1(L136Q) | |
| 200 μg | |
| Gln 23 - Gly 254 | |
| SDC1,Syndecan-1,CD138,SYND1,SDC | |
| FITC | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 25.8 kDa | |
| FITC-Labeled Human Syndecan-1, His Tag (SD1-HF228) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Gly 254 (Accession # P18827-1). | |
| -20°C, avoid light | |
| Syndecan-1 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Fluorescent labeled protein |