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ACROBiosystems FITC-Labeled Human Syndecan-1 Protein, His Tag

Marca:  ACROBiosystems SD1-HF228-200ug

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 17116701

  • dietro preventivo / 200µg

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Descrizione

Descrizione

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.8 kDa. The protein migrates as 42-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifica

Specifica

NP_001006947.1(L136Q)
25.8 kDa
200 µg
Gln 23 - Gly 254
SDC1,Syndecan-1,CD138,SYND1,SDC
FITC Labeled Protein
PBS, pH7.4
HEK293
Human
Powder
>90% as determined by SDS-PAGE
FITC-Labeled Human Syndecan-1, His Tag (SD1-HF228) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Gly 254 (Accession # P18827-1).
-20°C, avoid light
Syndecan-1
His Tag
Less than 1.0 EU / µg by the LAL method.
Fluorescent labeled protein
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