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GRP78/BIP Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 11587-1-AP-20UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16898763

  • 121.38€ / 20µL

Spedizione stimata: 29-09-2022
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Descrizione

Descrizione

11587-1-AP antibody recognizes one or two bands with MW 70-78 kDa for the signal peptide of GRP78 protein.

GRP78 is a 78 kDa glucose regulated protein that belongs to the family of heat shock proteins that include HSP70. GRP78 is a resident protein of the endoplasmic reticulum (ER) and associates transiently with a variety of newly synthesized secretory and membrane proteins. GRP78 may also interact with mutant and misfolded proteins, marking them for degradation. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C-terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP94) and protein disulfide isomerase (PDI). The KDEL signal is recognized by the KDEL receptor and this interaction ensures recycling of escaped ER proteins back to the ER. GRP78′s involvement in correct folding of proteins and degradation of misfolded proteins is via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate. GRP78 is critical for maintece of cell homeostasis and the prevention of apoptosis. GRP78 protein levels have been shown to be a reliable biomarker of hypoglycemia and serves a neuroprotective function in neurons exposed to glutamate and oxidative stress. GRP78 levels are reduced in the brains of Alzheimer′s Disease patients, and decreased expression of GRP78 is found associated with missense mutations in the human presenilin-1 (PS1) gene. Further, the induction of the GRP78 protein has been associated with the development of drug-resistance to antitumor drugs.
Specifica

Specifica

GRP78/BIP
Polyclonal
Unconjugated
HSPA5
BIP, GRP 78, GRP78, HSP A5, HSPA5, MIF2
Rabbit
Antigen Affinity Chromatography
RUO
14828, 25617, 3309
-20°C
Liquid
Immunocytochemistry, Flow Cytometry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)
0.57 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P06761, P11021, P20029
Hspa5
GRP78/BIP Fusion Protein Ag2188
20 μL
Primary
Rat, Human, Mouse
Antibody
IgG
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Offerte speciali

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