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ACROBiosystems Human CD40 Ligand / TNFSF5 Protein, Fc Tag (active trimer)
MALS verified
483.38€ - 3514.29€
Specifica
Numero di accesso | NP_000065.1 |
---|---|
Peso molecolare | 74.7 kDa |
Sorgente | Human CD40 Ligand, Fc Tag (active trimer) (MALS verified) (CDL-H5269) is expressed from human 293 cells (HEK293). It contains AA Gly 116 - Leu 261 (Accession # P29965-1) trimer Design. |
Immunogeno | Gly 116 - Leu 261 |
Requisiti di stoccaggio | -20°C |
Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
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Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
17106241
|
ACROBiosystems
CDL-H5269-100UG |
100 μg |
483.38€
100µg |
Spedizione stimata: 13-05-2024 Eseguire il login per visualizzare lo stock disponibile |
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso! | ||||
17116241
|
ACROBiosystems
CDL-H5269-1MG |
1 mg |
3514.29€
1mg |
Spedizione stimata: 13-05-2024 Eseguire il login per visualizzare lo stock disponibile |
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso! | ||||
Descrizione
CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members.CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 74.7 kDa. The protein migrates as 120-150 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.Specifica
NP_000065.1 | |
Human CD40 Ligand, Fc Tag (active trimer) (MALS verified) (CDL-H5269) is expressed from human 293 cells (HEK293). It contains AA Gly 116 - Leu 261 (Accession # P29965-1) trimer Design. | |
-20°C | |
CD40 Ligand | |
Human | |
50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5 | |
HEK293 | |
Immune Checkpoint Proteins |
74.7 kDa | |
Gly 116 - Leu 261 | |
CD40LG,CD154,CD40L,HIGM1,IGM,IMD3,T-BAM,TNFSF5,TRAP,gp39 | |
Unconjugated | |
Fc Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |