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ACROBiosystems Human GCGR / Glucagon receptor Protein, His Tag (MALS verified)
Marca: ACROBiosystems GCR-H52H3-50ug
Dettagli aggiuntivi : Peso : 0.00010kg
Descrizione
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.9 kDa. The protein migrates as 28-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifica
| NP_000151.1 | |
| >90% as determined by SDS-PAGE. | |
| Human GCGR, His Tag (GCR-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Lys 136 (Accession # P47871-1). | |
| -20°C | |
| GCGR | |
| His Tag | |
| Less than 0.1 EU / µg by the LAL method. | |
| Powder | |
| Human |
| 14.9 kDa | |
| 50 µg | |
| Ala 26 - Lys 136 | |
| Glucagon R, GCGR,Glucagon receptor | |
| Unconjugated | |
| PBS, pH7.4 | |
| HEK293 | |
| Bio-Markers & CD Antigens |