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IL-17F Mouse anti-Human, Mouse, Clone: 6H5F10, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 60245-1-IG-150UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16897275

  • 325.38€ / 150µL

Spedizione stimata: 04-10-2022
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Descrizione

Descrizione

IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils. IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. IL-17F may be secreted as a homodimer, or a heterodimer with IL17A. It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production. IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintece of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells. IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.
Specifica

Specifica

IL-17F
Monoclonal
0.95 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q7TNI7, Q96PD4
IL17F
IL-17F Fusion Protein Ag16310
150 μL
Primary
Mouse, Human
Antibody
IgG1
Western Blot
6H5F10
Unconjugated
IL17F
Cytokine ML 1, IL 17F, IL17F, IL-17F, interleukin 17F, ML 1, ML1
Mouse
Protein G
RUO
112744, 257630
-20°C
Liquid
Videos
SDS
Documenti
Certificati
Offerte speciali

Offerte speciali