Integrin alpha-4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Descrizione

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. The alpha 4 chain associates with either the beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4 beta1 and alpha4 beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4 beta7. It was also demonstrated that the HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4 beta7, the gut mucosal homing receptor for peripheral T cells.