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MYH9 Mouse anti-Human, Mouse, Porcine, Clone: 5D9D2, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 60233-1-IG-150UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16897255

  • 325.38€ / 150µL

Spedizione stimata: 28-09-2022
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Descrizione

Descrizione

TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer′s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
Specifica

Specifica

MYH9
Monoclonal
0.61 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P35579, Q8VDD5
Myh9
MYH9 Fusion Protein Ag1612
150 μL
Primary
Porcine, Mouse, Human
Antibody
IgG1
Western Blot, Immunofluorescence, Immunocytochemistry
5D9D2
Unconjugated
MYH9
DFNA17, EPSTS, FTNS, MHA, MYH9, Myosin 9, Myosin heavy chain 9
Mouse
Protein G
RUO
17886, 396904, 4627
-20°C
Liquid
Videos
SDS
Documenti
Certificati
Offerte speciali

Offerte speciali