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NASP Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 11323-1-AP-150UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16898313

  • 325.38€ / 150µL

Spedizione stimata: 04-10-2022
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Descrizione

Descrizione

This antibody can recognize both isoforms.

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3′ to 5′) activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation.
Specifica

Specifica

NASP
Polyclonal
Unconjugated
NASP
FLB7527, NASP, PRO1999
Rabbit
Antigen Affinity Chromatography
RUO
298441, 4678, 50927
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
0.32 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P49321, Q66HD3, Q99MD9
Nasp
NASP Fusion Protein Ag1824
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
Videos
SDS
Documenti
Certificati
Offerte speciali

Offerte speciali