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Phospho-Lck (Tyr505) Recombinant Rabbit Monoclonal Antibody (LckY505-A3), FITC, Invitrogen™
Rabbit Recombinant Monoclonal Antibody
185.00€ - 467.00€
Specifica
Antigene | Phospho-Lck (Tyr505) |
---|---|
Clone | LckY505-A3 |
Applicazioni | Flow Cytometry |
Classificazione | Monoclonal |
Coniugato | FITC |
Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
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Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
17186928
|
Thermo Scientific
MA537342 |
10 Tests |
185.00€
pezzi 10 |
Spedizione stimata: 31-05-2024 Eseguire il login per visualizzare lo stock disponibile |
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso! | ||||
17106688
|
Thermo Scientific
MA537094 |
100 Tests |
467.00€
pezzi 100 |
Spedizione stimata: 31-05-2024 Eseguire il login per visualizzare lo stock disponibile |
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso! | ||||
Descrizione
LCK is a member of the Src-family tyrosine kinase, which are essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, LCK phosphorylates the ITAM motives in its zeta subunits establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by LCK and activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. The majority of LCK is localized to the plasma membrane, however, there is also a significant fraction associated with the Golgi apparatus which may contribute to Raf activation under conditions of weak stimulation through the TCR. LCK contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors. Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternatively splice variants of the LCK gene encoding different isoforms of the protein have been found.Specifica
Phospho-Lck (Tyr505) | |
Flow Cytometry | |
FITC | |
Rabbit | |
Human | |
P06239 | |
3932 | |
A synthetic phospho-peptide corresponding to residues surrounding Tyr505 of human phospho Lck. | |
Primary | |
4° C, store in dark | |
LCK |
LckY505-A3 | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.20% BSA and 0.09% sodium azide | |
EC 2.7.10.2; Hck-3; IMD22; kinase Lck; Lck; LCK proto-oncogene, Src family tyrosine kinase; Lck1; Lcktkr; leukocyte C-terminal Src kinase; LSK; Lskt; Lsk-t; Lymphocyte cell-specific protein-tyrosine kinase; lymphocyte protein tyrosine kinase; lymphocyte-specific protein tyrosine kinase; OTTHUMP00000008640; OTTHUMP00000008740; OTTHUMP00000008741; p56(LSTRA) protein-tyrosine kinase; p56<lck>; p56lck; p56-LCK; pp58lck; Protein YT16; Proto-oncogene Lck; Proto-oncogene tyrosine-protein kinase LCK; RP4-675E8.4; t cell-specific protein-tyrosine kinase; T-lymphocyte specific protein tyrosine kinase p56lck; tyr; tyrosine-protein kinase Lck; YT16 | |
LCK | |
IgG κ | |
Protein A/G | |
Antibody |