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RAG2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 11825-1-AP-20UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16899153

  • 121.38€ / 20µL

Spedizione stimata: 06-10-2022
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Descrizione

Descrizione

This gene encodes a protein that is involved in the initiation of VJ recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Specifica

Specifica

RAG2
Polyclonal
Unconjugated
RAG2
RAG 2, RAG2
Rabbit
Antigen Affinity Chromatography
RUO
19374, 5897
-20°C
Liquid
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry, Immunoprecipitation
0.13 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P21784, P55895
RAG2
RAG2 Fusion Protein Ag2393
20 μL
Primary
Human, Mouse
Antibody
IgG
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Documenti
Certificati
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