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RIP3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 17563-1-AP-20UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16897474

  • 121.38€ / 20µL

Spedizione stimata: 11-10-2022
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Descrizione

Descrizione

RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif-mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2.
Specifica

Specifica

RIP3
Polyclonal
Unconjugated
RIPK3
Receptor interacting protein 3, RIP 3, RIP like protein kinase 3, RIP3, RIPK3
Rabbit
Antigen Affinity Chromatography
RUO
11035, 56532
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation
0.17 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q9QZL0, Q9Y572
Ripk3
RIP3 Fusion Protein Ag11759
20 μL
Primary
Mouse, Human
Antibody
IgG
Videos
SDS
Documenti
Certificati
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