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ACROBiosystems SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer

MALS verified

Marca:  ACROBiosystems SPN-C52H3-50ug

Dettagli aggiuntivi : Peso : 0.00010kg

 vedi altre versioni di questo prodotto

Codice prodotto. 17106771

  • dietro preventivo / 50µg

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Descrizione

Descrizione

It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 138.0 kDa. The protein migrates as 170-200 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifica

Specifica

QHD43416.1 (D614G)
138.0 kDa
50 µg
-20°C
S protein
His Tag
Less than 1.0 EU / µg by the LAL method.
Viral Proteins
Powder
>95% as determined by SDS-PAGE
SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer (SPN-C52H3) is the ectodomain of SARS-CoV-2 S protein that contains AA Val 16 - Pro 1213 (Accession # QHD43416.1) and D614G mutation, which has become increasingly common in SARS-CoV-2 viruses from around the world . The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag (at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.)
Spike,S protein,Spike glycoprotein,S glycoprotein,COVID-19
Unconjugated
PBS
HEK293
SARS-CoV-2
Videos
SDS
Documenti
Certificati
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