missing translation for 'onlineSavingsMsg'
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TERT Monoclonal Antibody (2C4), Invitrogen™
Mouse Monoclonal Antibody
Marca: Invitrogen MA516034
Dettagli aggiuntivi : Peso : 0.10000kg
Descrizione
Suggested positive control: 293T whole cell lysates, HeLa whole cell lysates, antigen standard for TERT (transient overexpression lysate).
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.Specifica
TERT | |
Monoclonal | |
1.0 mg/mL | |
PBS with 0.02% sodium azide | |
O14746, O70372, Q673L6 | |
TERT | |
Full-length recombinant hTERT from insect cells. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgM |
ChIP Assay, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
2C4 | |
Unconjugated | |
TERT | |
CMM9; DKCA2; DKCB4; EST2; HEST2; hTERT; hTRT; PFBMFT1; RGD:70494}; TCS1; Telomerase catalytic subunit; telomerase reverse transcriptase; telomerase reverse transcriptase beta; telomerase-associated protein 2; TERT; tert {ECO:0000312; TP2; TR; TRT | |
Mouse | |
IgM | |
RUO | |
21752, 301965, 7015 | |
-20°C or -80°C if preferred | |
Liquid |