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TIM3 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 4C4G3, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 60355-1-IG-150UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16897475

  • 349.00€ / 150µL

Spedizione stimata: 14-12-2022
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Descrizione

Descrizione

TIM3 is a 280 aa membrane protein with a calculated molecular weight of 33 kDa, the higher molecular weights between 50 and 70 kDa detected by this monoclonal antibody probably represent glycosylated TIM3.

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
Specifica

Specifica

TIM3
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P0C0K5, Q8TDQ0, Q8VIM0
Havcr2
TIM3 Fusion Protein Ag16901
150 μL
Primary
Rat, Porcine, Mouse, Human
Antibody
IgG1
Western Blot, Immunohistochemistry (Paraffin)
4C4G3
Unconjugated
HAVCR2
CD366, HAVcr 2, HAVCR2, KIM 3, T cell membrane protein 3, Tim 3, TIM3, TIM-3, TIMD 3, TIMD3
Mouse
Protein G
RUO
100522045, 171285, 363578, 84868
-20°C
Liquid
Videos
SDS
Documenti
Certificati
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Offerte speciali