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5 Lipoxygenase Mouse anti-Human, Porcine, Clone: 3B1B7, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 66326-1-IG-20UL

Dettagli aggiuntivi : Peso : 0.00010kg

 vedi altre versioni di questo prodotto

Codice prodotto. 16898095

  • 121.38€ / 20µL

Spedizione stimata: 11-10-2022
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Descrizione

Descrizione

The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LT) (Funk, 2001). Overproduction of LT contributes to several diseases, most notably chronic inflammatory diseases, including asthma (Drazen et al., 1994), fibrosis (Wilborn et al., 1996) and atherosclerosis (Dwyer et al., 2004). Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine-523 in 5-LO (Luo et al., 2004). Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, then, could contribute to a variety of diseases, including those characterized by chronic inflammation. The phospho-specific antibody to Ser523 on 5-LO is thus likely to provide a valuable toll for studies of the role of 5-LO regulation in diseases such as asthma, fibrosis and atherosclerosis.
Specifica

Specifica

5 Lipoxygenase
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P09917
ALOX5
5 Lipoxygenase Fusion Protein Ag18168
20 μL
Primary
Human, Porcine
Antibody
IgG2a
Immunohistochemistry (Paraffin), Western Blot
3B1B7
Unconjugated
ALOX5
5 lipoxygenase, 5 LO, 5 LOX, 5LPG, ALOX5, arachidonate 5 lipoxygenase, LOG5
Mouse
Protein A
RUO
100156205, 240
-20°C
Liquid
Videos
SDS
Documenti
Certificati
Offerte speciali

Offerte speciali