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ATR Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 19787-1-AP-20UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16899264

  • 121.38€ / 20µL

Spedizione stimata: 10-10-2022
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Descrizione

Descrizione

The antibody can recognize all the isoform of ATR.

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
Specifica

Specifica

ATR
Polyclonal
Unconjugated
ATR
ATR, FRAP related protein 1, FRP1, MEC1, SCKL, SCKL1
Rabbit
Antigen Affinity Chromatography
RUO
245000, 545, 685055
-20°C
Liquid
Western Blot, Immunohistochemistry (Paraffin)
0.28 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q13535, Q9JKK8
ATR
Peptide
20 μL
Primary
Mouse, Human, Rat
Antibody
IgG
Videos
SDS
Documenti
Certificati
Offerte speciali

Offerte speciali