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ACROBiosystems Biotinylated Human Angiopoietin-like 3 / ANGPTL3 Protein, His, Avitag™

Biotinylated Protein

Marca:  ACROBiosystems AN3-H82E7-200ug

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 17116071

  • dietro preventivo / 200µg

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Descrizione

Descrizione

Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 27.4 kDa. The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifica

Specifica

NP_055310
27.4 kDa
200 µg
Ser 17 - Pro 220
ANGPTL3,ANGPT5,ANG-5,Angiopoietin-5,FHBL2
Precision Avi
PBS, pH7.4
HEK293
Human
Powder
>90% as determined by SDS-PAGE
Biotinylated Human Angiopoietin-like 3, His,Avitag (AN3-H82E7) is expressed from human 293 cells (HEK293). It contains AA Ser 17 - Pro 220 (Accession # Q9Y5C1-1).
-20°C
Angiopoietin-like 3
His Tag and Avi Tag
Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
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