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Factor XII Mouse anti-Human, Clone: 2E2F11, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 66089-1-IG-20UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16897645

  • 129.00€ / 20µL

Spedizione stimata: 23-12-2022
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Descrizione

Descrizione

This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
Specifica

Specifica

Factor XII
Monoclonal
1.28 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P00748
F12
Factor XII Fusion Protein Ag3401
20 μL
Primary
Human
Antibody
IgG2b
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
2E2F11
Unconjugated
F12
Factor XII, Coagulation factor XII, F12, HAE3, HAEX, HAF, Hageman factor
Mouse
Protein A
RUO
2161
-20°C
Liquid
Videos
SDS
Documenti

Documenti

Certificati
Offerte speciali

Offerte speciali