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FAS/CD95 Mouse anti-Human, Mouse, Clone: 1G7F7, Proteintech
Mouse Monoclonal Antibody
Marca: Proteintech 60196-1-IG-150UL
Dettagli aggiuntivi : Peso : 0.00010kg
Descrizione
This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand.
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predomitly involved in anti-viral immune responses.Specifica
FAS/CD95 | |
Monoclonal | |
1.13 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P25445, P25446 | |
FAS | |
FAS/CD95 Fusion Protein Ag3718 | |
150 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG1 |
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot | |
1G7F7 | |
Unconjugated | |
FAS | |
ALPS1A, APO 1, Apo 1 antigen, APT1, CD95, FAS, FAS1, FASLG receptor, FASTM, TNFRSF6 | |
Mouse | |
Protein G | |
RUO | |
14102, 355 | |
-20°C | |
Liquid |