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FAS/CD95 Mouse anti-Human, Mouse, Clone: 1G7F7, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 60196-1-IG-150UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16897185

  • 325.38€ / 150µL

Spedizione stimata: 11-10-2022
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Descrizione

Descrizione

This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand.

FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predomitly involved in anti-viral immune responses.
Specifica

Specifica

FAS/CD95
Monoclonal
1.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P25445, P25446
FAS
FAS/CD95 Fusion Protein Ag3718
150 μL
Primary
Mouse, Human
Antibody
IgG1
Western Blot, Immunohistochemistry (Paraffin), Flow Cytometry
1G7F7
Unconjugated
FAS
ALPS1A, APO 1, Apo 1 antigen, APT1, CD95, FAS, FAS1, FASLG receptor, FASTM, TNFRSF6
Mouse
Protein G
RUO
14102, 355
-20°C
Liquid
Videos
SDS
Documenti
Certificati
Offerte speciali

Offerte speciali