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IL-4 Mouse, anti-Human, R718, Clone: MP4-25D2, BD Horizon™

Mouse Monoclonal Antibody

Marca:  BD Biosciences 566980

Dettagli aggiuntivi : Peso : 0.00060kg

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Codice prodotto. 17297764

  • 533.00€ / 100 tests

Spedizione stimata: 28-02-2023
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Descrizione

Descrizione

The MP4-25D2 monoclonal antibody specifically binds to Interleukin-4 (IL-4). IL-4 is also known as Lymphocyte stimulatory factor 1, B cell stimulatory factor 1 (BSF-1), or B cell growth factor 1 (BCGF-1). IL-4 is produced by activated T cells, basophils, and mast cells. IL-4 is a multifunctional cytokine and growth factor that affects a variety of different target cell types. IL-4 can costimulate T cell proliferation and survival, as well as help drive Th2-like cell differentiation and effector functions. It costimulates B cell proliferation and survival, and can help B cells differentiate into IgG4- or IgE-producing cells. IL-4 can also diminish the proinflammatory functions of monocytes and macrophages. IL-4 exerts its biological effects by binding with high affinity to cell surface CD124 (IL-4Rα chain). CD124 forms signaling IL-4 receptor complexes with either CD132/common γ chain or CD213a1/IL-13Rα1 to form either Type I or Type II IL-4 Receptor complexes, respectively. The immunogen used to generate the MP4-25D2 hybridoma was purified recombinant human IL-4. This is a neutralizing antibody. The MP4-25D2 antibody has been reported to crossreact with IL-4 from rhesus monkeys. The use of the MP4-25D2 antibody for epitope mapping of human IL-4 has been described.

Specifica

Specifica

IL-4
Monoclonal
R718
100 Tests
Primary
Refrigerate Upon Arrival
Flow Cytometry
MP4-25D2
Mouse
RUO
Human
Liquid
Videos
SDS
Documenti

Documenti

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