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ING4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 10617-1-AP-20UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16897103

  • 129.00€ / 20µL

Spedizione stimata: 22-12-2022
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Descrizione

Descrizione

This antibody is a rabbit polyclonal antibody raised against full length human ING4 antigen.

The ING4 gene belongs to the ING (Inhibitor of Growth) family of tumor suppressors. All five members of the ING protein family identified to date contain a highly conserved plant homeodomain (PHD) finger motif at the C-terminal end, which is found in transcription factors that modulate chromatin structure. ING proteins have been shown to form transcriptional complexes leading to activation of responsive genes that mediate a wide range of cellular functions, including growth arrest, DNA repair, gene transcription, apoptosis, and senescence. The candidate tumor suppressor ING4 has a role in brain tumor pathogenesis, and is involved in regulating tumor growth and angiogenesis. Expression of ING4 is reduced in gliomas compared to normal brain tissue, and ING4 reduction correlates with progression from lower to higher grades of tumors. ING4 physically interacts with the p65 (RelA) subunit of NF-kB and represses transcription of NF-kB responsive genes. Inactivating mutations in ING4 transcripts have been described in various human cancer cell lines, and deletion of the ING4 locus has been detected in 10-20% of human breast cancer cell lines and tumors.
Specifica

Specifica

ING4
Polyclonal
Unconjugated
ING4
ING4, Inhibitor of growth protein 4, my036, p29ING4
Rabbit
Antigen Affinity Chromatography
RUO
28019, 297597, 51147
-20°C
Liquid
Western Blot, Immunoprecipitation
0.13 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q8C0D7, Q9UNL4
Ing4
ING4 Fusion Protein Ag0960
20 μL
Primary
Rat, Mouse, Human
Antibody
IgG
Videos
SDS
Documenti

Documenti

Certificati
Offerte speciali

Offerte speciali