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ACROBiosystems Mouse Nectin-4 Protein, Fc Tag (MALS verified)
Brand: ACROBiosystems NE4-M5257-1mg
Additional Details : Peso : 0.00010kg
Description
Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.8 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
| NP_082169.2 | |
| 1 mg | |
| Gly 31 - Ser 347 | |
| NECTIN4,LNIR, PRR4, PVRL4 | |
| Unconjugated | |
| Fc Tag | |
| Less than 0.1 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE. |
| 60.8 kDa | |
| Mouse Nectin-4, Fc Tag (NE4-M5257) is expressed from human 293 cells (HEK293). It contains AA Gly 31 - Ser 347 (Accession # Q8R007-1). | |
| -20°C | |
| Nectin-4 | |
| Mouse | |
| 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| Immune Checkpoint Proteins |