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ACROBiosystems SARS S protein (R667A, K968P, V969P), His Tag (MALS verified)
Marca: ACROBiosystems SPN-S52H6-1mg
Dettagli aggiuntivi : Peso : 0.00010kg
Descrizione
It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 136.3 kDa. The protein migrates as 190-210 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifica
| AAP13567.1 (R667A, K968P, V969P) | |
| 1 mg | |
| Ser 14 - Pro 1195 | |
| Spike,S protein,Spike glycoprotein,S glycoprotein,COVID-19 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE. |
| 136.3 kDa | |
| SARS S protein (R667A, K968P, V969P), His Tag (SPN-S52H6) is expressed from human 293 cells (HEK293). It contains AA Ser 14 - Pro 1195 (Accession # AAP13567.1 (R667A, K968P, V969P)). The recombinant protein is expressed with T4 fibritin trimerization motif and a polyhistidine tag (at the C-terminus. Proline substitutions (K968P, V969P) and alanine substitutions (R667A) are introduced to stabilize the trimeric prefusion state of SARS-CoV S protein and abolish the furin cleavage site, respectively.) | |
| -20°C | |
| S protein | |
| SARS | |
| PBS | |
| HEK293 | |
| Viral Proteins |